Personal Information on this Website/Creator:

Name: Dr. William C. Brumley (Bill)
Occupation: Research Chemist with U.S. EPA
Research Interests: Trace organic analysis, instrumental analysis (GC/MS, LC/MS, CE/LIF, multidimensional separations (HPLC and CE), sample handling (SPE), extraction/cleanup (ASE, HPGPC)
Hobbies: Siamese cats, computer programming, Bible study
Site maintenance: Site will be updated irregularly with new quotes, verse study, list study, and doctrine. A new book entiltled Short Bible will be excerpted.
Bugs will be addressed as I am able since I am moving on to Linux and other areas. Site is enhanced for MSIE via marquees and java applets. If you do not agree with my theology or think you find me in error, let us be kind to each other because we may end up disagreeing but do not have to be disagreeable.

Chemistry Matters

The following instrumentation is available for collaboration in environmental analysis: H-P 1090 HPLCs with DAD and FLD; H-P GC/MSD 6890 with CI; Beckman HPLC with DAD; Beckman P/ACE 2000 and 5000 with LIF; Coherent Innova 70 Ar/Kr ion and FReD 300 Ar ion lasers for CE/LIF; Spex Fluorolog 2; Spectrum One CCD with controller and software (SpectraMax) from Instruments, SA; Finnigan-MAT 900S-Trap; H-P 5890 GC/ECD; H-P 5890 GC/NPD; HeCd lasers at 325 nm and 354 nm; HeNe lasers at 595 nm and 633 nm; VG 70SE GC/MS; Dionix ASE 200; H-P SFE; Suprex SFE; Waters automated HPGPC; Camag TLC spotter and densitometer; all instruments with supporting data systems.

Separations:
HPLC: Development of liquid separations for various analytes using porous graphitic carbon columns in both the reverse phase mode and normal phase mode. Efforts to take advantage of this unique phase which appears to be well matched to environmental analysis. Anticipatory and relevant to existing problems. Implementation of two-dimensional separations based on fractionation from C18 RPHPLC fed to porous graphitic carbon columns. Solves two problems: dilution of sample and speed required for second dimension. Addresses the need for increased peak capacity in analysis of complex matrices. Multidimensional separations provides a framework for any pesticide residue problem in environmental analysis; currently looking at HPGPC, RPHPLC, CZE, and porous graphitic carbon. Systematizes the analytical problem into one, two, or three dimensional separations depending on detector, residue level, and matrix interferences.
PCBs: Fractionation of most toxic PCB isomers with HPLC using porous graphitic carbon column. This work is being broadened to include the polybrominated diphenyl ethers.
Electrophoresis: This work has been most practically focused on groundwater tracers using LIF detection. Pharmaceuticals and Personal Care Products (PPCPs): Characterization of waste streams and detection of various compounds including base/neutrals and acids. Extension to amine containing acids as well.

Detection:
Laser-induced fluorescence (LIF) and detection limits: Liquid separations and low detection limits using LIF address future anticipated problems requiring LC separations and extremely low detection limits; tie in to new high-resolution mass spectrometer and LC/MS and CE/MS techniques. Positions EPA to handle nonvolatile compounds introduced by commerce into the environment.
LIF detection using the frequency-doubled laser is being expanded in applications beyond PNAs to anionic and cationic compounds in extracts of contaminated soils. Phenols are currently under study with an emphasis on EDC candidates. LIF provides fundamental insight into exposure processes and a sensitive screening tool for mass spectral confirmation. We are establishing ourselves as a leading laboratory in this field with frequency-doubled laser, multiwavelength laser, HeCd near UV lasers, and visible region lasers with a strong tie in to the new HRMS for unknowns and characterizing biomarkers.
Developing a CE/LIF format using visible region for immunoassay using herbicides as an example target; this allows for LIF detection limits without derivatization at ppb and sub-ppb levels.
Carrying out the experiments for doing full emission spectra recording on the fly for CZE/LIF with better qualitative identification and quantitation based on the full spectrum.Sample preparation:
Solvent extraction research: Initiating fish extractions for determining background levels and reagent blanks for future sample work. Most work is planned for accelerated solvent extraction (ASE) technique with some portions undergoing SFE and Soxhlet reference extractions.Environmental Monitoring:
EDC Screening: Developing a RT data base for common target compounds for EDCs using GC/ECD and GC/NPD to supplement screening and GC/MS analyses.
Pesticides: Developing a microbore HPLC multi residue screening procedure for 50 to 100 pesticides likely to be encountered from high density agricultural activity such as in California San Joaquin Valley. HRMS: New HRMS involving CE/MS and LC/MS projects especially in the context of multiresidue analysis.Why it is important Methods development (and the overall role of analytical chemistry) is important since it undergirds the regulatory aspects, the cleanup, and the understanding of the environment. Methods are found explicitly in the numbered U.S. EPA Methods that are known worldwide for reliable environmental analysis. Continuous improvements to methods are recognized in the ORD Strategic Plan for improving the reliability of environmental measurements, for lowering costs of analyses, and for reducing worker exposure while simultaneously reducing waste production from the analytical operations. New substances continuously enter the environment as they become new members of the chemicals of commerce. Many of these are specifically earmarked for environmental applications or become of environmental interest due to their applications in related fields of medicine, food, water treatments, crop control, and industrial use. Methods are subject to continuous improvements in techniques, technology, and invention of new tools as is any field of science and technology. Our role in ORD is both short range and long range. Short range goals include improvements to existing methods that respond to research needs that we as experts perceive, needs created by new program initiatives such as EDCs and DISPro, needs stated by program offices, and needs prioritized by regional scientists. Longer range goals include our role of capturing the best of the new developments and new tools emerging in diverse areas of chemistry, biochemistry, physics, and biology. It is recognized that biochemistry and the biomedical fields have currently stimulated much growth in instrumental capabilities to enable the solution of difficult analytical problems. This growth has in turn stimulated our own efforts to develop liquid separations and their interfacing to mass spectrometry as well as our efforts to study the fundamental biochemical indicators of exposure including biological specimens and proteins.


Completed Journal Papers (2006):

1. C. C. Hinckley and W. C. Brumley, "Effects of Random Coordinate Error in Analyses of Lanthanide-Induced Pseudocontact Shifts. Axially Symmetric Case," J. Am. Chem. Soc., 98, 1331-1336 (1976).

2. C. C. Hinckley and W. C. Brumley, "Errors in Analyses of Lanthanide-Induced Shifts. cis- and trans-Pinocarveol, " J. Magn. Resonance, 24, 239-250 (1976).

3. T. McNeal, W. C. Brumley, C. Breder, and J. A. Sphon, "Gas-Solid Chromatographic-Mass Spectrometric Confirmation of Low Levels of Acrylonitrile After Distillation from Food-Simulating Solvents," J. Assoc. Off. Anal. Chem., 62, 41-46 (1979).

4. P. A. Dreifuss, G. E. Wood, J. A. G. Roach, W. C. Brumley, D. A. Andrzejewski, and J. A. Sphon, "Field Desorption Mass Spectrometry of Cyanogenic Glycosides," Biomed. Mass Spectrom., 7, 201-204 (1980).

5. J. Sphon, D. Andrzejewski, W. Brumley, P. Dreifuss, and J. Roach, "The Application of Mass Spectrometry to the Analysis of Food Toxicants," in Advances in Mass Spectrometry, Vol 8B, A. Quayle, ed., Heyden, London, 1980, pp. 1490-1498.

6. W. C. Brumley and J. A. Sphon, "Regulatory Mass Spectrometry," Biomed. Mass Spectrom., 8, 390-396 (1981).

7. J. A. G. Roach, A. J. Malatesta, J. A. Sphon, W. C. Brumley, D. Andrzejewski, P. A. Dreifuss, "Construction of Desorption Chemical Ionization Probe for Activated Field Desorption Emitters," Int. J. Mass Spectrom. Ion Phys., 39, 151-156 (1981).

8. W. C. Brumley, J. A. G. Roach, J. A. Sphon, P. A. Dreifuss, D. A. Andrzejewski, R. A. Niemann, and D. Firestone, "Low Resolution Multiple Ion Detection GC/MS Comparison of Extraction-Cleanup Methodology for Determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Fish," J. Agric. Food Chem., 29, 1040-1046 (1981).

9. W. C. Brumley, S. Nesheim, M. Trucksess, E. W. Trucksess, P. A. Driefuss, J. A. G. Roach, D. A. Andrzejewski, R. M. Eppley, A. E. Pohland, C. W. Thorpe, and J. A. Sphon, "Negative Ion Chemical Ionization Mass Spectrometry of Aflatoxins and Related Mycotoxins," Anal. Chem., 53, 2003-2006 (1981).

10. D. F. Hunt, T. M. Harvey, W. C. Brumley, F. F. Ryan, III, and J. W. Russell, "Nitric Oxide Chemical Ionization Mass Spectra of Alcohols," Anal. Chem., 54, 492-496 (1982).

11. W. C. Brumley and C. C. Hinckley, "Spectroscopic Properties of Os(VI) Monoesters Containing Heterocyclic Nitrogen Ligands," J. Inorg. Nucl. Chem., 42, 1277-1284 (1980).

12. W. C. Brumley, D. Andrzejewski, W. W. Trucksess, P. A. Dreifuss, J. A. G. Roach, R. M. Eppley, F. S. Thomas, C. W. Thorpe, and J. A. Sphon, "Negative Ion Chemical Ionization Mass Spectrometry of Trichothecenes; Novel Fragmentation under OH- Conditions," Biomed. Mass Spectrom., 9 451-458 (1982).

13. S. Nesheim and W. Brumley, "Confirmation of Identity of Aflatoxins," J. Am. Oil Chemists' Soc., 58, 945A-949A 1981).

14. M. W. Trucksess, L. Stoloff, W. C. Brumley, D. M. Wilson, O. M. Hale, L. T. Sangster, D. M. Miller, "Aflatoxicol and Aflatoxins B1 and M1 in the Tissues of Pigs Receiving Aflatoxin," J. Assoc. Off. Anal. Chem., 65, 884-887 (1983).

15. R. C. Snyder, W. C. Brumley, and C. V. Breder, "Confirmation of 2,4- and 2,6-Toluenediamine in Aqueous Extracts by LC/GC and LC/GC/MS," J. Assoc. Off. Anal. Chem., 65, 1388-1392 (1982).

16. K. D. White, A. Min, W. C. Brumley, R. Krause, and J. A. Sphon, "Comparison of GC/MS and LC/MS Methods for the Confirmation of Coumaphos and Its Oxygen Analog in Eggs and Milk," J. Assoc. Off. Anal. Chem., 66, 1358-1364 (1983).

17. W. C. Brumley, Z. Min, J. E. Matusik, C. J. Barnes, and J. A. Sphon, "Identification of Sulfonamide Drugs in Animal Tissues by Mass Analyzed Ion Kinetic Energy Spectroscopy," Anal. Chem., 55, 1405-1409 (1983).

18. R. A. Niemann, W. C. Brumley, D. Firestone, and J. A. Sphon, "Multidimensional High Resolution Chromatographic Analysis of Fish for 2,3,7,8-Tetrachlorodibenzo-p-dioxin with Parts-per-Trillion Quantitation by Capillary Gas Chromatography with Electron Capture Detection," Anal. Chem., 55, 1497-1504 (1983).

19. A. Joshi, Z. Min, W. C. Brumley, P. A. Dreifuss, G. C. Yang, and J. A. Sphon, "Mass Spectrometry of the Copper Salt of Tenuazonic Acid," Biomed. Mass Spectrom., 11, 101-105 (1984).

20. M. W. Trucksess, J. L. Richard, L. Stoloff, J. S. McDonald, and W. C. Brumley, "Absorption and Distribution Patterns of Aflatoxicol and Aflatoxins B1 and M1 in Blood and Milk of Cows Following Oral Administration of Aflatoxin B1," Am. J. of Veterinary Res., 44, 1753-1756 (1983).

21. P. A. Dreifuss, E. A. Caress, W. C. Brumley, and J. A. Sphon, "Negative Ion Chemical Ionization Mass Spectrometry of Pyrrolizidine Alkaloids," Anal. Chem., 55, 1036-1040 (1983).

22. A. M. Gardner, M. P. Yurawecz, W. C. Cunningham, G. W. Diachenko, E. P. Mazzola, and W. C. Brumley, "Isolation and Identification of C16 and C18 Fatty Acid Esters of Chloropropanediol in Adulterated Spanish Cooking Oils," Bull. Environ. Contam. Toxicol., 31, 625-630 (1983).

23. W. C. Brumley, C. Warner, D. Daniels, D. Andrzejewski, K. D. White, Z. Min, J. Y. T. Chem, and J. A. Sphon, "Characterization of Polysorbates by OH- Negative Ion Chemical Ionization Mass Spectrometry," J. Agric. Food Chem., 33, 368-372 (1985).

24. W. C. Brumley, M. W. Trucksess, S. H. Adler, C. Cohen, K. D. White, and J. A. Sphon, "Negative Ion Chemical Ionization Mass Spectrometry of Deoxynivalenol (DON): Application to Determination of DON in Grains and Snack foods," J. Agric. Food Chem., 33, 326-330 (1985).

25. M. W. Trucksess, W. C. Brumley, and S. Nesheim, "Rapid Quantitation and Confirmation of Aflatoxins in Corn and Peanut Butter Using a Disposable Silica Gel Column, Thin Layer Chromatography, and Gas Chromatography/Mass Spectrometry," J. Assoc. Off. Anal. Chem., 67, 973-975 (1984).

26. W. C. Brumley, A. J. Sheppard, T. S. Rudolf, C.-S. J. Shen, P. Yasaei, and J. A. Sphon, "The Mass Spectrometry and Identification of Sterols in Vegetable Oils As Butyryl Esters and Relative Quantitations by Gas Chromatography/Flame Ionization Detection," J. Assoc. Off. Anal. Chem., 68, 701-709 (1985).

27. D. F. Hunt, W. C. Brumley, G. C. Stafford, and F. K. Botz, "Analysis of Polycyclic Aromatic Hydrocarbons by Pulsed Positive-Negative Ion CIMS with Oxygen as the Reagent Gas," Pract. Spectrosc., 3, 327-328 (1980).

28. D. L. Park, V. DiProssimo, E. Abdel-Malek, M. W. Trucksess, S. Nesheim, W. C. Brumley, J. A. Sphon, T. L. Barry, and G. Petzinger, "Negative Ion Chemical Ionization Mass Spectrometric Confirmation Method for the Confirmation of Identity of Aflatoxin B1: Collaborative Study," J. Assoc. Off. Anal. Chem., 68, 636-640 (1985).

29. W. C. Brumley, D. Andrzejewski, and J. A. Sphon, "Collisionally Activated Mass Spectra of (M-H)- Ions of Polyhydroxy and Hydroxyether Compounds," Org. Mass Spectrom., 23, 204-212 (1988).

30. W. C. Brumley, B. J. Canas, G. A. Perfetti, M. Mossoba, J. A. Sphon, and P. E. Corneliussen, "Quantitation of Ethyl Carbamate in Whiskey, Sherry, Port, and Wine by GC/MS/MS Using a Triple Quadrupole Mass Spectrometer," Anal. Chem., 60, 975-978 (1988).

31. W. C. Brumley, G. M. Brilis, R. J. Calvey, and J. A. Sphon, "Collisional Activation Mass Spectra of M-. Ions of Azo Dyes Containing 2-Naphthol," Biomed. Environ. Mass Spectrom., 18, 394-400 (1989).

32. W. C. Brumley, C. R. Warner, D. H. Daniels, S. Varner, and J. A. Sphon, "EI Mass Spectrometry of BHT and Its Alteration Products," Biomed. Mass Spectrom., 18, 207-217 (1989).

33. G. M. Brilis and W. C. Brumley, "Electron Capture Negative Ionization Calibrants for Magnetic Sector Mass Spectrometers," Anal. Chim. Acta., 229, 163-168 (1990).

34. J. Yinon, W. C. Brumley, and G. M. Brilis, "Mass Spectral Fragmentation Pathways in Nitramines. A Collision-Induced Study," Org. Mass Spectrom., 25, 14-20 (1990).

35. J. R. Donnelly, A. H. Grange, N. J. Nunn, G. W. Sovocool, W. C. Brumley, and R. K. Mitchum, "Analysis of Thermoplastic Resins for Brominated Dibenzofurans," Biomed. Environ. Mass Spectrom., 18, 884-888 (1989).

36. P. Yasaei, A. J. Sheppard, W. C. Brumley, E. P. Mazzola, and M. H. Aldridge, "Structural Proof of Cholesterol Isolated from Plants. II. Identification and Verification by Carbon-13 Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry," J. Micronutr. Anal., 5, 259-267 (1989).

37. W. C. Brumley, C. M. Brownrigg, and G. M. Brilis, "Characterization of Nitrogen-Containing Aromatic Compounds in Soil and Sediment by GC/MS After Fractionation," J. Chromatogr., 558, 223-233 (1991).

38. A. H. Grange and W. C. Brumley, "Plotting Ion Profiles from Selected-ion Recording Data," Rapid Commun. Mass Spectrom., 6, 68-70 (1992).

39. W. C. Brumley, "Qualitative Analysis of Environmental Samples for Aromatic Sulfonic Acids by High Performance Capillary Electrophoresis," J. Chromatogr., 603, 267-272 (1992).

40. E. P. Mazzola, R. J. Calvey, W. C. Brumley, M. B. Meyers, S. J. Bell, S. E. Lenzenweger, and W. F. Reynolds, "Structural Determination of an FD&C Red No. 3 Contaminant," Dyes and Pigments, 18, 81-89 (1992).

41. W. C. Brumley, C. M. Brownrigg, and A. H. Grange, "Determination of Toxaphene in Soil by Electron Capture Negative Ion Mass Spectrometry After Fractionation by High Performance Gel Permeation Chromatography," J. Chromatogr., 633, 177-183 (1993).

42. W. C. Brumley and C. M. Brownrigg, "Electrophoretic Behavior of Aromatic-Containing Organic Acids and the Determination of Selected Compounds in Water and Soil by Capillary Electrophoresis," J. Chromatogr., 646, 377-389 (1993).

43. W. C. Brumley and C. M. Brownrigg, "Applications of Micellar Electrokinetic Chromatography in the Determination of Benzidines Following Extraction from Water, Soil, Sediment, and Chromatographic Adsorbents," J. Chromatogr. Sci., 32, 69-75 (1994).

44. W. C. Brumley, E. M. Shafter, and P. E. Tillander, "The Determination of Phthalates in Water and Soil by Tandem Mass Spectrometry Using Isobutane Chemical Ionization Mass Spectrometry," J. Assoc. Off. Anal. Chem., 77, 1-8 (1994).

45. W. C. Brumley, C. M. Brownrigg, and A. H. Grange, "Capillary Liquid Chromatography/Mass Spectrometry and Micellar Electrokinetic Chromatography as Complementary Techniques in Environmental Analysis," J. Chromatogr., 680, 635-642 (1994).

46. W. C. Brumley and W. J. Jones, "Comparison of Micellar Electrokinetic Chromatography with Capillary Gas Chromatography in the separation of phenols, anilines, and polynuclear aromatics: Potential Field-Screening Applications of MEKC," J. Chromatogr., 680, 163-173 (1994).

47. A. H. Grange, J. R. Donnelly, W. C. Brumley, S. A. Billets, and G. W. Sovocool, "Mass Measurements by an Accurate and Sensitive Selected-Ion-Recording Technique," Anal. Chem., 66,4416-4421 (1994).

48. W. C. Brumley, W. J. Jones, and A. H. Grange, "A Survey of PotentialApplicationsof High Temperature Capillary Gas Chromatography to Environmental Analysis", LCCGC, 13, 228-238 (1995).

49. M. Jung and W. C. Brumley, "Trace Analysis of Fluorescein-Derivatized Phenoxy Acid Herbicides by Micellar Electrokinetic Chromatography with Laser-induced Fluorescence Detection," J. Chromtagr. A, 717, 299-308 (1995).

50. W. H. Matchett and W. C. Brumley, "Preconcentration of Aliphatic Amines from Water Determined by Capillary Electrophoresis with Indirect UV Detection," J. Liq. Chromatogr., 20, 79-100 (1997).

51. W. Winnik, L. D. Betowski, and W. C. Brumley, "Negative Ion Mass Spectrometry of Sufonylurea Herbicides," J. Mass Spectrom., 30, 1574-1580 (1995).

52. W. C. Brumley, "Micellar Electrokinetic Chromatography: A New Tool for Field-Screening of Semivolatiles," Proceedings of the Fourth International Symposium on Field Screening Methods for Hazardous Waste and Toxic Chemicals, February 22-24, 1995, Las Vegas, NV; (sponsored by Air & Waste Management Association).

53. W. C. Brumley, "Environmental Applications of Capillary Electrophoresis for Organic Pollutant Determination," LCCGC, 13, 556-568 (1995).

54. W. Winnik, W. C. Brumley , and L. D. Betowski, "Negative-Ion FAB Mass Spectrometry of Sufonylurea Herbicides," European Mass Spectrom., 2, 43-47 (1996).

55. W. C. Brumley, "Techniques for Handling Environmental Samples with Potential for Capillary Electrophoresis," J. Chromatogr. Sci., 33, 670-685 (1995).

56. A. H. Grange and W. C. Brumley, "Mass Peak Profiling from Selected Ion Recording Data Acquired at High Mass Resolution: An Important New Analytical Technique for Mass Spectral Determinations," Environ. Testing and Analysis, March/April, 22-26, 1996.

57. A. H. Grange, J. R. Donnelly, G. W. Sovocool, and W. C. Brumley, "Determination of Elemental Compositions from Mass Peak Profiles of the Molecular Ion (M) and the M+1 and M+2 Ions," Anal. Chem., 68, 553-560 (1996).

58. A. H. Grange and W. C. Brumley, "Determining Elemental Compositions from Exact Masses and Relative Abundances of Ions," Trends Anal. Chem., 15, 12-17 (1996).

59. C. M. Pace, J. R. Donnelly, J. L. Jeter, W. C. Brumley, and G. W. Sovocool, "Determination of Aromatic Amines in Soils," J. AOAC Internat., 79, 777-783 (1996).

60. J. R. Donnelly, A. H. Grange, N. R. Herron, G. R. Nickhol, J. L. Jeter, R. J. White, and W. C. Brumley, and J. Van Emon, "Modular Methodology for Determination of Polychlorinated Biphenyls in Soil as Aroclors and Individual Congeners," J. AOAC Internat., 79, 953-961(1996).

61. W. H. Matchett, W. Winnik, and W. C. Brumley, "Capillary Electrophoretic Behavior of Seven Sulfonylurea Herbicides," J. Cap. Electrophoresis, 3, 199-204 (1996).

62. W. H. Matchett, W. Winnik, and W. C. Brumley, "A Kinetic Study of the Methanolysis of the Sulfonylureas Bensulfuron and Sulfometuron Using Capillary Electrophoresis," Electrophoresis, 18, 205-213 (1997).

63. A. H. Grange and W. C. Brumley, "Identification of Components in a Complex Mixture by Determination of Exact Masses and Relative Abundances using Mass Peak Profiling," LC!GC, 14, 978-986 (1996).

64. A. H. Grange and W. C. Brumley, "A Mass Peak Profile Generation Model to Facilitate Determination of Elemental Compositions of Ions Based on Exact Masses and Isotopic Abundances," J. Am. Soc. Mass Spectrom., 8, 170-182 (1997).

65. W. C. Brumley and V. Kelliher, "Determination of Aliphatic Amines in Water Using Derivatization with Fluorescein Isothiocyanate and Capillary Electrophoresis/Laser-Induced Fluorescence Detection," J. Liq. Chromatogr., 20, 2193-2205 (1997).

66. W. C. Brumley, P. L. Ferguson, A. H. Grange, J. L. Donnelly, and J. W. Farley, "Applications of Capillary Electrophoresis/ Laser-Induced Fluorescence Detection to Groundwater Migration Studies," J. Cap. Electrophoresis, 3, 295-299 (1996).

67. W. C. Brumley, E. Latorre, V. Kelliher, A. Marcus, and D. Knowles, "Determination of Chlordane in Soil by LC/GC/ECD and GC/EC NIMS with Comparison of ASE, SFE, and Soxhlet Extraction," J. Liq. Chromatogr., 21, 1199-1216 (1998).

68. P. L. Ferguson, A. H. Grange, W. C. Brumley, J. L. Donnelly, and J. W. Farley, "Capillary Electrophoresis/Laser-Induced Fluorescence Detection of Fluorescein as a Groundwater Migration Tracer," Electrophoresis, 19, 2252-2256 (1998).

69. T. W. Moy, P. L. Ferguson, A. H. Grange, W. H. Matchett, V. A. Kelliher, and W. C. Brumley, "Development of Separation Systems for Hydrophobic Environmental Contaminants Using Micellar Electrokinetic Chromatography with Molecular Micelles," Electrophoresis, 19, 2090-2094 (1998).

70. W. C. Brumley, A. H. Grange, V. Kelliher, D. B. Patterson, A. Montcalm, J. Glassman, and J. Farley, "Environmental Screening of Acidic Compounds Based on CZE/LIF Detection with GC/MS and GC/HRMS Identifications," JAOAC International, accepted, 2/00.

71. K. R. Rogers, A. B. Apostol, and W. C. Brumley, "Capillary Electrophoresis (CE) Immunoassay Format for Phenoxyacid Herbicides," Anal. Lett., 33, 443-453 (2000).

72. G. Wayne Sovocool, W. C. Brumley, J. R. Donnelly, "Capillary Electrophoresis and Capillary Electrochromatography of Organic Pollutants," Electrophoresis, 20, 3297-3310 (1999).

73. W. C. Brumley and C. Gerlach, " Capillary Electrophoresis/Laser-induced Fluorescence in Groundwater Migration Determination," Am. Lab., 31, 45-49 (1999) .

74. N.R. Herron, J. R. Donnelly, G. R. Nichol, and W. C. Brumley, "Microwave Heating to Facilitate Supercritical Fluid Extractions," Amer. Environ. Lab., 10, pp. 1, 5 (1998).

75. W. C. Brumley, A. H. Grange, V. Kelliher, D. B. Patterson, A. Montcalm, J. Glassman, and J. W. Farley, "Environmental Screening of Acidic Compounds Based on CZE/LIF Detection with GC/MS and GC/HRMS Identifications," JAOAC International, 83, 1059-1067 (2000).

76. D. B. Patterson, W. C. Brumley, V. Kelliher, and P. L. Ferguson, "Determination of Clofibric Acid in Sewage Effluent by GC/MS: Conversion to the Methyl Ester with Trimethylsilyldiazomethane," Amer. Lab. 34, 20-28 (2002).

77. S. Flaherty, S. Wark, G. Street, J.W. Farley, and W. C. Brumley, "Investigation of CE/LIF as a Tool in the Characterization of Sewage Effluent for Fluorescent Acidics: Determination of Salicylic Acid", Electrophoresis 23, 2327-2332 (2002).

78. T. A. Moy and W. C. Brumley, "MultiResidue Determination of Acidic Pesticides in Water by HPLC/DAD with Confirmation by GC/MS Using Conversion to the Methyl Ester with Trimethylsilyldiazomethane," J. Chromatogr.Sci. 47, 343-349 (2003).

79. L. Riddick, E.L. Gentry, M. McDaniel, and W. C. Brumley, “Comparison of N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide with trimethylsilyl reagents for environmental analysis under both EIMS and electron capture NICIMS conditions " Internat. J. Environ. Anal. Chem. 86, 299-312 (2006).

80. W. C. Brumley and J. W. Farley, "Application of a multiwavelength laser to the capillary electrophoresis/laser-induced fluorescence determination of eosin as a groundwater migration tracer," Electrophoresis, 24, 2335-2339 (2003).

81. M. A. Mottaleb, W. C. Brumley, S. M. Pyle and G. W. Sovocool, “Determination of a Bound Musk Xylene Metabolite in Carp Hemoglobin as a Biomarker of Exposure by Gas Chromatography Mass Spectrometry Using Selected Ion Monitoring,” J. Anal. Toxicol., 28 (6), 581-586 (2004).

82. M A. Mottaleb, W. C. Brumley, and G. Wayne Sovocool, “Comparison of Determining Bound Musk Metabolites in Carp Hemoglobin Using EIMS and Electron Capture Negative Ion MS,” Intern. J. Environ. Anal. Chem., 84 (14-15), 1069-1078 (2004).

83. M. A. Mottaleb, W. C. Brumley, L. R. Curtis, G.W. Sovocool, “Nitro musk adducts of rainbow trout hemoglobin: Dose-response and toxicokinetics determination by GC-NICI-MS for a sentinel species,” Am. Biotechnol. Lab. 23(7), 24, 26-29 (2005).

Click on the links within the listings below to view abstracts and full reproduction of submitted forms of selected papers with figures.

Click on the link below to get the overview of trace organic analysis.

For another view of trace organic analysis visit my "official site" at the link below.








Last updated: 10 June 2006